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Overdose

Human Experience:
There have been 3 cases of sertraline overdosage (approximately 4 to 10 times the maximum recommended daily dose). These 3 patients recovered completely without the need for spec ific therapy

Side Effects of This Medicine

Side effects from Zoloft are common:

- upset stomach
- drowsiness
- weakness or tiredness
- excitement or anxiety
- insomnia
- nightmares
- dry mouth
- ski n more sensitive to sunlight than usual
- changes in appetite or weight

Tell your doctor if any of these symptoms are severe or do not go away:

- constipation
- difficult y urinating
- frequent urination
- blurred vision
- changes in sex drive or ability
- excessive sweating

What special precautions should I follow?

Older adults¡XIn studies done to date that have included elderly people, Zoloft did not cause different side effects or problems in older people than it did in younger adults. However, this medicine m y be removed from the body more slowly in older adults. An older adult may receive a lower dose of Zoloft than a younger adult, especially when first starting treatment.

Description

Zoloft is prescribed for major depressive disorder¡Xa persistently low mood that interferes with everyday living. Symptoms may include loss of interest in your usual activities, disturbed sleep, chang in appetite, constant fidgeting or lethargic movement, fatigue, feelings of worthlessness or guilt, difficulty thinking or concentrating, and recurrent thoughts of suicide.

How to Use

Take this medicine only as directed by your doctor, to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doc tor ordered.

Zoloft may be taken with or without food on a full or empty stomach. If your doctor tells you to take it a certain way, follow your doctor's instructions.

You may have to take Zoloft for 4 weeks or longer before you begin to feel better. Your doctor should check your progress at regular visits during this time. Also, if you are taking this medicine for depression, y ou may need to keep taking it for 6 months or longer to help prevent the return of the depression.

Adverse Effects

In clinical development programs, sertraline has been evaluated in 1902 subjects with depression. The most commonly observed adverse events associated with the use of sertraline were: gastrointestinal complaints, including nausea, diarrhea/loose stools and dyspepsia; male sexual dysfunction (primarily ejaculatory delay); insomnia and somnolence; tremor; increased sweating and dry mouth; and dizzin ess. In the fixed dose placebo controlled study, the overall incidence of side effects was dose related with a majority occurring in the patients treated with 200 mg dose.

The discontinuatio n rate due to adverse events was 15% in 2710 subjects who received sertraline in premarketing multiple dose clinical trials.


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