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Possible food and drug interactions when taking this medication

Seizures: - During clinical trials, the overall incidence of seizures was 0.15% in patients treated with paroxetine. However, patients with a history of convulsive disorders were excluded from these s tudies. Caution is recommended when the drug is administered to patients with a history of seizures. The drug should be discontinued in any patient who develops seizures.

Overdose

Overdose attempts have been reported with paroxetine; up to 850 mg alone and in combination with other agents. In cases where paroxetine was used alone, no deaths have occurred and recovery was medica lly uneventful.

Symptoms of overdosage with paroxetine include nausea, vomiting, tremor, dilated pupils, dry mouth and irritability. There are no reports of ECG abnormalities, coma or convul sions following overdosage with paroxetine alone.

Precautions while Using this Medicine

The presence of other medical problems may affect the use of Paxil. Make sure you tell your doctor if you have any other medical problems, especially:
- Brain disease or damage or
- Mental r etardation or
- Epilepsy or seizures (history of)¡XThe risk of seizures may be increased.
- Glaucoma, narrow angle¡XPatients with this condition should use Paxil with caution.
- Heart d ease or
- Heart attack, recent¡XUse must be determined by your doctor.
- Kidney disease, severe, or
- Liver disease, severe¡XHigher blood levels of Paxil may occur, increasing the chanc of side effects
- Mania (history of)¡XThe condition may be activated

Side Effects

If you experience any of the following symptoms, call your doctor immediately:

- jaw, neck, and back muscle spasms
- slow or difficult speech
- shuffling walk
- persistent fin e tremor or inability to sit still
- fever, chills, sore throat, or flu-like symptoms
- difficulty breathing or swallowing
- severe skin rash
- yellowing of the skin or eyes
- irregular heartbeat

What Is It

Paxil is used to treat depression, obsessive-compulsive disorders, panic attacks, social anxiety disorder, generalized anxiety disorder, and posttraumatic stress disorder. Paxil controlled-release (P axil CR) is used to treat depression and panic attacks. Paxil is in a class of medications called selective serotonin reuptake inhibitors (SSRIs). It works by increasing the amounts of certain natural substances in the brain.

Precautions Before Using This Medicine

Older adults¡XIn studies that have included elderly people, Paxil did not cause different side effects or problems in older people than it did in younger adults. However, Paxil may be removed from the body more slowly in elderly people. An older adult may need a lower dose than a younger adult.


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